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Cristina Zuccato Selected Research

Fetal Hemoglobin (Hemoglobin F)

4/2024Increased Expression of α-Hemoglobin Stabilizing Protein (AHSP) mRNA in Erythroid Precursor Cells Isolated from β-Thalassemia Patients Treated with Sirolimus (Rapamycin).
12/2023New Synthetic Isoxazole Derivatives Acting as Potent Inducers of Fetal Hemoglobin in Erythroid Precursor Cells Isolated from β-Thalassemic Patients.
10/2023Effects of Mithramycin on BCL11A Gene Expression and on the Interaction of the BCL11A Transcriptional Complex to γ-Globin Gene Promoter Sequences.
10/2023Decrease in α-Globin and Increase in the Autophagy-Activating Kinase ULK1 mRNA in Erythroid Precursors from β-Thalassemia Patients Treated with Sirolimus.
9/2023The Long Scientific Journey of Sirolimus (Rapamycin): From the Soil of Easter Island (Rapa Nui) to Applied Research and Clinical Trials on β-Thalassemia and Other Hemoglobinopathies.
1/2023The rs368698783 (G>A) Polymorphism Affecting LYAR Binding to the Aγ-Globin Gene Is Associated with High Fetal Hemoglobin (HbF) in β-Thalassemia Erythroid Precursor Cells Treated with HbF Inducers
9/2022Co-Treatment of Erythroid Cells from β-Thalassemia Patients with CRISPR-Cas9-Based β039-Globin Gene Editing and Induction of Fetal Hemoglobin.
1/2022A Rational Approach to Drug Repositioning in β-thalassemia: Induction of Fetal Hemoglobin by Established Drugs.
1/2022Expression of γ-globin genes in β-thalassemia patients treated with sirolimus: results from a pilot clinical trial (Sirthalaclin).
12/2021Treatment of Erythroid Precursor Cells from β-Thalassemia Patients with Cinchona Alkaloids: Induction of Fetal Hemoglobin Production.
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Cristina Zuccato Research Topics

Disease

28Thalassemia
04/2024 - 01/2008
8Sickle Cell Anemia (Hemoglobin S Disease)
10/2023 - 02/2008
6beta-Thalassemia (Cooley's Anemia)
04/2016 - 02/2008
5Hemoglobinopathies
10/2023 - 10/2020
3Neoplasms (Cancer)
04/2013 - 08/2009
3Skin Diseases (Skin Disease)
10/2009 - 02/2008
2Hematologic Diseases (Blood Diseases)
01/2015 - 02/2012
2BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
04/2013 - 09/2010
2Psoriasis (Pustulosis Palmaris et Plantaris)
10/2009 - 08/2009
2Mycosis Fungoides
10/2009 - 08/2009
1Systemic Lupus Erythematosus (Libman-Sacks Disease)
07/2023
1Cytopenia
07/2023
1Lymphangioleiomyomatosis (Lymphangiomyomatosis)
07/2023
1Hemolysis
01/2023
1Rare Diseases (Rare Disease)
01/2022
1Asymptomatic Diseases
01/2017
1Infections
12/2013
1Inborn Genetic Diseases (Disease, Hereditary)
12/2013
1Cystic Fibrosis (Mucoviscidosis)
12/2013
1Anemia
06/2012
1Blast Crisis (Blast Phase)
09/2010
1Pleural Effusion (Pleural Effusions)
09/2010
1Vitiligo
10/2009
1Eczema
10/2009
1Leukemia
02/2008

Drug/Important Bio-Agent (IBA)

24Fetal Hemoglobin (Hemoglobin F)IBA
04/2024 - 01/2008
22GlobinsIBA
04/2024 - 01/2008
10Hemoglobins (Hemoglobin)IBA
04/2024 - 11/2009
8Messenger RNA (mRNA)IBA
04/2024 - 06/2009
7Sirolimus (Rapamycin)FDA Link
04/2024 - 01/2022
5Proteins (Proteins, Gene)FDA Link
04/2024 - 12/2013
3Furocoumarins (Furanocoumarins)IBA
09/2010 - 02/2008
3Photosensitizing Agents (Photosensitizers)IBA
10/2009 - 02/2008
2ErythropoietinFDA Link
11/2023 - 02/2012
2PlicamycinFDA Link
10/2023 - 01/2015
2MicroRNAs (MicroRNA)IBA
01/2015 - 02/2012
2AminoglycosidesIBA
12/2013 - 11/2009
2beta-Globins (beta Globin)IBA
11/2009 - 01/2008
2Codon (Codons)IBA
11/2009 - 01/2008
2gamma-GlobinsIBA
10/2009 - 06/2009
1IsoxazolesIBA
12/2023
1VaccinesIBA
11/2023
1BNT162 VaccineIBA
11/2023
1SARS-CoV-2 spike proteinIBA
11/2023
1Phosphotransferases (Kinase)IBA
10/2023
1Cinchona AlkaloidsIBA
12/2021
1cinchonidineIBA
12/2021
1Quinidine (Chinidin)FDA LinkGeneric
12/2021
1Small Molecule LibrariesIBA
10/2020
1DNA (Deoxyribonucleic Acid)IBA
01/2017
1Hydroxyurea (Hydrea)FDA LinkGeneric
01/2017
15' Untranslated Regions (5' UTR)IBA
01/2017
1OligodeoxyribonucleotidesIBA
01/2015
1Tobramycin (Nebcin)FDA LinkGeneric
12/2013
1Anti-Bacterial Agents (Antibiotics)IBA
12/2013
1AntioxidantsIBA
06/2012
1ResveratrolIBA
06/2012
15-MethoxypsoralenIBA
09/2010
1antibiotic G 418IBA
11/2009
1Plant ExtractsIBA
06/2009
1Ficusin (Psoralen)IBA
02/2008
1NucleotidesIBA
01/2008

Therapy/Procedure

11Therapeutics
10/2023 - 02/2008
2Precision Medicine
01/2023 - 01/2022
1Organ Transplantation
07/2023
1Off-Label Use
01/2022
1Investigational Therapies (Experimental Therapy)
11/2019
1Bone Marrow Transplantation (Transplantation, Bone Marrow)
04/2016